Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 6/20 | 0.46 |
| ▸ | PLG | P00747 | 4/20 | 0.46 |
| ▸ | PLAT | P00750 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834790 | 1.00 | TRPV1 (0.48) | TRPV1ADORA3PLAUPLGPLAT | |
| SCHEMBL4840822 | 0.95 | NPC1 (0.49) | MAPTKDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL4840832 | 0.95 | NPC1 (0.49) | MAPTKDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL4835360 | 0.95 | KCNK9 (0.47) | TRPV1ADORA3MAPTKDM4EALDH1A1 | |
| SCHEMBL4835346 | 0.95 | KCNK9 (0.47) | TRPV1ADORA3MAPTKDM4EALDH1A1 | |
| SCHEMBL4839109 | 0.93 | RAB9A (0.49) | PLAUMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4839102 | 0.93 | RAB9A (0.49) | PLAUMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4844588 | 0.92 | TRPV1 (0.53) | TRPV1ADORA3MAPTKDM4EALDH1A1 | |
| SCHEMBL4844570 | 0.92 | TRPV1 (0.53) | TRPV1ADORA3MAPTKDM4EALDH1A1 | |
| SCHEMBL4835216 | 0.90 | NPC1 (0.51) | MAPTKDM4EALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378428-B2 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-27 | — | — | US | disclosed |
| US-20050222138-A1 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222138-A1 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | PARK7, MMP8, CDK7 | TRPV1 1672/4885ADORA3 1555/4885PLAU 1618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.