Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 6/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845667 | 0.99 | CHEK2 (0.55) | CHEK2ACHEHRH3KCNH2TBK1 | |
| SCHEMBL4844287 | 0.95 | ACHE (0.62) | CHEK2ACHEHRH3TBK1IKBKE | |
| SCHEMBL4844406 | 0.94 | ACHE (0.61) | CHEK2ACHETBK1IKBKE | |
| SCHEMBL4834143 | 0.90 | TBK1 (0.59) | ACHEHRH3KCNH2TBK1IKBKE | |
| SCHEMBL5260732 | 0.88 | ACHE (0.55) | CHEK2ACHEHRH3TBK1IKBKE | |
| SCHEMBL4837368 | 0.86 | HRH3 (0.52) | CHEK2ACHEHRH3TBK1IKBKE | |
| Trifluoroacetic Acid SCHEMBL4842116 | 0.85 | CHEK2 (0.53) | CHEK2ACHETBK1IKBKEDHODH | |
| SCHEMBL4843624 | 0.84 | ACHE (0.50) | CHEK2ACHETBK1IKBKEDRD3 | |
| SCHEMBL4834923 | 0.84 | ACHE (0.62) | ACHETBK1IKBKE | |
| SCHEMBL4846045 | 0.84 | ACHE (0.52) | CHEK2ACHETBK1IKBKEDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | claimed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | claimed |
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | CHEK2 309/4885ACHE 1390/4885HRH3 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.