Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.55 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.53 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837368 | 0.95 | HRH3 (0.52) | ACHETBK1IKBKECHEK2HRH3 | |
| SCHEMBL4844287 | 0.93 | ACHE (0.62) | ACHETBK1IKBKECHEK2ADORA3 | |
| SCHEMBL4844406 | 0.92 | ACHE (0.61) | ACHETBK1IKBKECHEK2ADORA3 | |
| SCHEMBL4834824 | 0.88 | CHEK2 (0.56) | ACHETBK1IKBKECHEK2HRH3 | |
| Trifluoroacetic Acid SCHEMBL5260784 | 0.88 | CHEK2 (0.47) | ACHETBK1IKBKECHEK2CDK2 | |
| SCHEMBL4845667 | 0.87 | CHEK2 (0.55) | ACHETBK1IKBKECHEK2HRH3 | |
| SCHEMBL6270456 | 0.86 | TBK1 (0.46) | ACHETBK1IKBKECHEK2CDK2 | |
| SCHEMBL4840409 | 0.86 | ACHE (0.48) | ACHETBK1IKBKECHEK2HRH3 | |
| SCHEMBL4845601 | 0.84 | ACHE (0.48) | ACHETBK1IKBKECHEK2ADORA3 | |
| SCHEMBL4838294 | 0.84 | TBK1 (0.48) | ACHETBK1IKBKECHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | claimed |