SCHEMBL483530

SCHEMBL483530

Cc1cc(C(=O)c2ccc(N=C=S)c(C)c2)ccc1N=C=S

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.44
HTT P42858 1/20 0.44
LMNA P02545 4/20 0.40
NPC1 O15118 2/20 0.40
MITF O75030 1/20 0.40
POLB P06746 1/20 0.40
ALDH1A1 P00352 8/20 0.39
MAPT P10636 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35
GAA P10253 1/20 0.34
MAPK1 P28482 1/20 0.34
SRD5A2 P31213 1/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
SLC22A6 Q4U2R8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29874662 1.00 SMN1; SMN2 (0.44) SMN1; SMN2HTTLMNANPC1MITF
SCHEMBL3398382 0.88 TSHR (0.44) SMN1; SMN2POLBALDH1A1MAPTTDP1
SCHEMBL9712538 0.86 ALDH1A1 (0.35) SMN1; SMN2HTTLMNAPOLBALDH1A1
SCHEMBL3670437 0.86 PARP1 (0.41) SMN1; SMN2LMNAALDH1A1KMT2A
SCHEMBL11188602 0.84 CYP3A4 (0.46) SMN1; SMN2HTTLMNANPC1MITF
SCHEMBL7119247 0.83 CA1 (0.45) SMN1; SMN2HTTLMNAALDH1A1MAPT
SCHEMBL28559554 0.83 TDP1 (0.34) SMN1; SMN2HTTLMNAPOLBALDH1A1
SCHEMBL942142 0.79 CES2 (0.38) SMN1; SMN2HTTLMNANPC1ALDH1A1
SCHEMBL6371682 0.76 ESR2 (0.37) LMNANPC1POLBALDH1A1MAPT
SCHEMBL1993331 0.75 ALDH1A1 (0.41) LMNAPOLBALDH1A1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 312 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748866-A1 AQUEOUS POLYURETHANE DISPERSIONS AND APPLICATIONS THEREOF Covestro Deutschland AG (DE) 2026-05-27 EP disclosed
EP-4396248-B1 AQUEOUS POLYURETHANE-UREA DISPERSION COVESTRO DEUTSCHLAND AG (DE) 2025-08-06 EP disclosed
US-12359016-B2 Method of preparing low haze polymer compositions for use in high refractive index optical materials PPG INDUSTRIES OHIO, INC. (US) 2025-07-15 US disclosed
EP-3841141-B1 A COMPOSITION, PREPARATION METHOD AND APPLICATION THEREOF COVESTRO DEUTSCHLAND AG (DE) 2025-01-01 EP disclosed
US-20240368425-A1 Aqueous Polyurethane-Urea Dispersion COVESTRO DEUTSCHLAND AG (DE) 2024-11-07 US disclosed
EP-3643735-B1 PHOTOCHROMIC POLYROTAXANE COMPOUND, AND CURABLE COMPOSITION CONTAINING SAID PHOTOCHROMIC POLYROTAXANE COMPOUND TOKUYAMA CORP (JP) 2024-07-31 EP disclosed
EP-4396248-A1 AQUEOUS POLYURETHANE-UREA DISPERSION Covestro Deutschland AG (DE) 2024-07-10 EP disclosed
US-11965108-B2 Composition, preparation method and application thereof COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2024-04-23 US disclosed
US-11965092-B2 Polyurethane composition, preparation method and application thereof COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2024-04-23 US disclosed
US-20240034828-A1 Aqueous Polyurethane Urea Dispersion COVESTRO DEUTSCHLAND AG (DE) 2024-02-01 US disclosed
US-5352758-A Polythiourethane formed by reaction of specific mercaptan with polyisocyanate or polyisothiocyanate MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1994-10-04 US disclosed
EP-0351073-B1 Lens comprising a resin having a large refractive index and process for preparing the lens MITSUI TOATSU CHEMICALS (JP) 1994-09-21 EP disclosed
US-5283312-A Colorless, transparent, high refractive index, heat resistance, low dispersion; polythiourethanes MITSUI TOATSU CHEMICALS, INC. (JP) 1994-02-01 US disclosed
EP-0553801-A1 Use of sulfur-containing acid phosphoric ester as internal release agent MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-08-04 EP disclosed
EP-0378895-B1 A MERCAPTO COMPOUND, A HIGH REFRACTIVE INDEX RESIN AND LENS AND A PROCESS FOR PREPARING THEM MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-07-14 EP disclosed
US-5191055-A Polythiourethanes MITSUI TOATSU CHEMICALS, INC. (JP) 1993-03-02 US disclosed
EP-0528590-A1 Mercapto compound, its preparation process, and sulfur-containing urethane resins and lenses using the same MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-02-24 EP disclosed
US-5087758-A Polythiourethane monomer MITSUI TOATSU CHEMICALS, INC. (JP) 1992-02-11 US disclosed
US-5084545-A Polythiourethanes for impact strength, lightweight lenses MITSUI TOATSU CHEMICALS, INC. (JP) 1992-01-28 US disclosed
EP-0378895-A1 A mercapto compound, a high refractive index resin and lens and a process for preparing them MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-07-25 EP disclosed