Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPD | P32754 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483226 | 1.00 | HPD (0.40) | HPDSCN3AEGFRGSK3BKCNH2 | |
| SCHEMBL483534 | 0.95 | HPD (0.39) | HPDSCN3AEGFRGSK3BKCNH2 | |
| SCHEMBL483703 | 0.91 | MAOB (0.40) | SCN3AKCNH2PARP15PARP10RAB9A | |
| SCHEMBL484166 | 0.91 | MAOB (0.40) | SCN3AKCNH2PARP15PARP10RAB9A | |
| SCHEMBL310837 | 0.86 | MAOB (0.41) | SCN3AKCNH2PARP15PARP10RAB9A | |
| SCHEMBL483563 | 0.86 | MAOB (0.41) | SCN3AKCNH2PARP15PARP10RAB9A | |
| SCHEMBL483746 | 0.84 | HPD (0.39) | HPDSCN3AKCNH2MEN1KMT2A | |
| SCHEMBL2835406 | 0.75 | HPD (0.42) | HPDSCN3AKCNH2MEN1KMT2A | |
| SCHEMBL2834518 | 0.75 | HPD (0.42) | HPDSCN3AKCNH2MEN1KMT2A | |
| SCHEMBL483474 | 0.75 | GRIN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |