Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484224 | 0.81 | HSD17B10 (0.34) | GRIN1GRIN2AGRIN2BOPRD1OPRM1 | |
| SCHEMBL484225 | 0.81 | HSD17B10 (0.34) | GRIN1GRIN2AGRIN2BOPRD1OPRM1 | |
| SCHEMBL483691 | 0.80 | GRIN1 (0.35) | GRIN1GRIN2AGRIN2B | |
| SCHEMBL483539 | 0.75 | HPD (0.40) | — | |
| SCHEMBL5527373 | 0.69 | OPRD1 (0.46) | OPRD1OPRM1OPRK1 | |
| SCHEMBL484166 | 0.69 | MAOB (0.40) | — | |
| SCHEMBL2837258 | 0.68 | KIF11 (0.37) | OPRD1OPRM1OPRK1 | |
| SCHEMBL483473 | 0.65 | NR1H2 (0.38) | OPRK1 | |
| SCHEMBL7679805 | 0.60 | FNTA (0.44) | OPRD1OPRM1OPRK1 | |
| SCHEMBL7680809 | 0.60 | FNTA (0.44) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |