SCHEMBL483563

SCHEMBL483563

CC(C)(C)[C@]1(c2ccc(OCc3ccccc3F)cc2)CC[C@@]2(CCNC2=O)N1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.41
PARP15 Q460N3 1/20 0.39
PARP14 Q460N5 1/20 0.39
PARP10 Q53GL7 1/20 0.39
SCN9A Q15858 2/20 0.38
KCNH2 Q12809 6/20 0.37
MMP1 P03956 2/20 0.37
ADAM17 P78536 1/20 0.37
SCN3A Q9NY46 6/20 0.37
SCN1A P35498 1/20 0.37
SCN4A P35499 1/20 0.37
SCN7A Q01118 1/20 0.37
SCN5A Q14524 1/20 0.37
SCN2A Q99250 1/20 0.37
SCN8A Q9UQD0 1/20 0.37
SCN10A Q9Y5Y9 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2B6 P20813 1/20 0.36
CYP2C19 P33261 1/20 0.36
OPRM1 P35372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL310837 1.00 MAOB (0.41) MAOBPARP15PARP14PARP10SCN9A
SCHEMBL483703 0.95 MAOB (0.40) MAOBPARP15PARP14PARP10SCN9A
SCHEMBL484166 0.95 MAOB (0.40) MAOBPARP15PARP14PARP10SCN9A
SCHEMBL483534 0.91 HPD (0.39) MAOBPARP15PARP10KCNH2SCN3A
SCHEMBL483669 0.87 FFAR1 (0.42) MAOBKCNH2MMP1ADAM17
SCHEMBL483226 0.86 HPD (0.40) MAOBPARP15PARP10KCNH2MMP1
SCHEMBL483539 0.86 HPD (0.40) MAOBPARP15PARP10KCNH2MMP1
SCHEMBL310843 0.85 MAOB (0.42) MAOBPARP15PARP14PARP10SCN9A
SCHEMBL483746 0.77 HPD (0.39) MAOBPARP15PARP10KCNH2MMP1
SCHEMBL2835400 0.75 KCNH2 (0.50) MAOBPARP15PARP14PARP10SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153623-B2 Compounds Convergence Pharmaceuticals Limited (GB) 2012-04-10 US disclosed
EP-1934176-B1 QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS GLAXO GROUP LTD (GB) 2012-02-01 EP disclosed