Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310837 | 0.87 | MAOB (0.41) | ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL483563 | 0.87 | MAOB (0.41) | ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL484166 | 0.82 | MAOB (0.40) | ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL483703 | 0.82 | MAOB (0.40) | ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL483534 | 0.78 | HPD (0.39) | MAOBKCNH2 | |
| SCHEMBL2832503 | 0.76 | KCNH2 (0.49) | FFAR1ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL310843 | 0.74 | MAOB (0.42) | ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL483226 | 0.74 | HPD (0.40) | ADAM17MMP1MAOBKCNH2SPHK2 | |
| SCHEMBL483666 | 0.74 | KCNH2 (0.45) | FFAR1ADAM17MMP1MAOBKCNH2 | |
| SCHEMBL483539 | 0.74 | HPD (0.40) | ADAM17MMP1MAOBKCNH2SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |