Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 17/20 | 0.63 |
| ▸ | CTSK | P43235 | 12/20 | 0.46 |
| ▸ | CTSB | P07858 | 10/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
| ▸ | CTSC | P53634 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834550 | 1.00 | CTSS (0.63) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL4838374 | 0.90 | CTSS (0.52) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL6062590 | 0.90 | CTSS (0.52) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL4831977 | 0.85 | CTSS (0.48) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL7070923 | 0.83 | CTSS (0.46) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL5368724 | 0.82 | CTSS (0.53) | CTSSCTSKCTSBCTSLCTSC | |
| Hydrochloric Acid SCHEMBL6095937 | 0.81 | CTSS (0.52) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL4840219 | 0.81 | CTSS (0.43) | CTSSCTSKCTSBCTSLCTSC | |
| SCHEMBL4836327 | 0.80 | CTSS (0.69) | CTSSCTSKCTSBCTSL | |
| SCHEMBL11889813 | 0.80 | CTSS (0.62) | CTSSCTSKCTSBCTSLCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465745-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7326719-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-20050222145-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| US-20040180886-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180886-A1 | Cathepsin S inhibitors | CTSS, CTSB, CTSZ | CTSS 1/4885CTSK 7/4885CTSB 2/4885 |
| US-20050222145-A1 | Cathepsin S inhibitors | CTSS, CTSB, CTSZ | CTSS 1/4885CTSK 7/4885CTSB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.