Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836078 | 1.00 | MAPK14 (0.56) | MAPK14MEN1KMT2ACDK2GSK3B | |
| SCHEMBL4836694 | 0.91 | MAPK14 (0.57) | MAPK14MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4836698 | 0.91 | MAPK14 (0.57) | MAPK14MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4607994 | 0.88 | MAPK14 (0.60) | MAPK14GSK3B | |
| SCHEMBL4608337 | 0.88 | MAPK14 (0.60) | MAPK14GSK3B | |
| SCHEMBL4832071 | 0.87 | MAPK14 (0.57) | MAPK14MEN1KMT2A | |
| SCHEMBL4832061 | 0.87 | MAPK14 (0.57) | MAPK14MEN1KMT2A | |
| SCHEMBL4608972 | 0.87 | MAPK14 (0.59) | MAPK14RAB9ASMN1; SMN2 | |
| SCHEMBL4609947 | 0.87 | MAPK14 (0.59) | MAPK14ALDH1A1RAB9A | |
| SCHEMBL4609953 | 0.87 | MAPK14 (0.59) | MAPK14ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402589-B2 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2008-07-22 | — | — | US | claimed |
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | IL1B, IL1A, IL6 | MAPK14 2674/4885MEN1 3574/4885KMT2A 3914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.