Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833062 | 0.88 | PDE10A (0.35) | — | |
| SCHEMBL1573859 | 0.85 | GAA (0.41) | KDM4EMAPTALDH1A1TRPC3TRPC6 | |
| SCHEMBL1574095 | 0.74 | HRH3 (0.40) | TP53 | |
| SCHEMBL1573883 | 0.74 | GAA (0.41) | KDM4EALDH1A1TP53HPGD | |
| SCHEMBL1574115 | 0.73 | GAA (0.41) | KDM4EMAPTALDH1A1TP53HPGD | |
| SCHEMBL1573785 | 0.73 | SPR (0.37) | — | |
| SCHEMBL1573815 | 0.72 | GAA (0.43) | KDM4EMAPTALDH1A1TRPC3TRPC6 | |
| SCHEMBL1573819 | 0.72 | GAA (0.40) | ALDH1A1TRPC3TRPC6TP53HPGD | |
| SCHEMBL1573910 | 0.72 | KMT2A (0.41) | KDM4EMAPTALDH1A1TP53HPGD | |
| SCHEMBL1573988 | 0.71 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937648-B1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI SA (FR) | 2014-11-26 | — | — | EP | disclosed |
| EP-1937648-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | sanofi-aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042178-A1 | DIACYL INDAZOL DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-04-19 | — | — | WO | disclosed |