Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 2/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566447 | 0.84 | KCNJ1 (0.46) | HSD17B1MAPTSMN1; SMN2CYP2A6CYP2B6 | |
| SCHEMBL29790306 | 0.84 | KCNJ1 (0.46) | HSD17B1MAPTSMN1; SMN2CYP2A6CYP2B6 | |
| SCHEMBL15274452 | 0.84 | KCNJ1 (0.46) | HSD17B1MAPTSMN1; SMN2CYP2A6CYP2B6 | |
| SCHEMBL2042090 | 0.83 | BCL2L1 (0.59) | CYP2A6CYP2B6CYP2E1DHODHMKNK1 | |
| SCHEMBL29788190 | 0.83 | BCL2L1 (0.59) | CYP2A6CYP2B6CYP2E1DHODHMKNK1 | |
| SCHEMBL22801121 | 0.82 | MAP4K4 (0.57) | MKNK2JAK2RETKDRGSK3A | |
| SCHEMBL2806084 | 0.81 | MKNK1 (0.58) | SMN1; SMN2MKNK1MKNK2MMP2MMP9 | |
| SCHEMBL22575207 | 0.81 | CSNK2A1 (0.52) | SMN1; SMN2CYP2A6CYP2B6CYP3A4CYP2C19 | |
| SCHEMBL23500079 | 0.79 | MAPT (0.53) | HSD17B1MAPTSMN1; SMN2KIF11XDH | |
| SCHEMBL1138580 | 0.79 | HSD17B1 (0.53) | HSD17B1MAPTSMN1; SMN2XDHMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12486246-B2 | Replication protein A (RPA)-DNA interaction inhibitors | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2025-12-02 | — | — | US | disclosed |
| US-20230056729-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | NATIONAL INSTITUTES OF HEALTH | 2023-02-23 | — | — | US | disclosed |
| EP-4073055-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | The Trustees of Indiana University (US) | 2022-10-19 | — | — | EP | disclosed |
| WO-2021119242-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2021-06-17 | — | — | WO | disclosed |
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2411057-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2550255-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2016-04-27 | — | — | EP | disclosed |
| EP-2550255-B1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | LILLY CO ELI (US) | 2016-04-27 | — | — | EP | disclosed |
| US-20130302248-A1 | Imaging Agents for Detecting Neurological Disorders | LILLY CO ELI (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130302248-A1 | Imaging Agents for Detecting Neurological Disorders | LILLY CO ELI (US) | 2013-11-14 | — | — | US | disclosed |
| WO-2011119565-A1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119565-A1 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| WO-2010111303-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111303-A2 | IMAGING AGENTS FOR DETECTING NEUROLOGICAL DISORDERS | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| US-20100239496-A1 | Imaging agents for detecting neurological disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100239496-A1 | Imaging agents for detecting neurological disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100239496-A1 | Imaging agents for detecting neurological disorders | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486246-B2 | Replication protein A (RPA)-DNA interaction inhibitors | RPA1, RPA3, RPAP1 | HSD17B1 3780/4885MAPT 3496/4885SMN1; SMN2 4309/4885 |
| US-20130302248-A1 | Imaging Agents for Detecting Neurological Disorders | MAPT, APP, PSEN1 | HSD17B1 3176/4885MAPT 1/4885SMN1; SMN2 39/4885 |
| US-20230056729-A1 | REPLICATION PROTEIN A (RPA)-DNA INTERACTION INHIBITORS | RPA1, RPA3, RPAP1 | HSD17B1 3780/4885MAPT 3496/4885SMN1; SMN2 4309/4885 |
| US-20110182812-A1 | Imaging Agents for Detecting Neurological Disorders | MAPT, APP, PSEN1 | HSD17B1 3770/4885MAPT 1/4885SMN1; SMN2 26/4885 |
| US-20100239496-A1 | Imaging agents for detecting neurological disorders | MAPT, APP, PSEN1 | HSD17B1 3176/4885MAPT 1/4885SMN1; SMN2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.