Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311818 | 1.00 | EGFR (0.53) | EGFRMAOBL3MBTL1NR4A1NR4A2 | |
| SCHEMBL483716 | 0.89 | PTPN1 (0.53) | MAOBNR4A1NR4A2NR4A3MEN1 | |
| SCHEMBL310957 | 0.87 | MAOB (0.51) | EGFRMAOBL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL840032 | 0.86 | EGFR (0.50) | EGFRMAOBL3MBTL1NR4A1NR4A2 | |
| SCHEMBL3350999 | 0.83 | ITGB3 (0.55) | MAOBNR4A1NR4A2NR4A3MAPT | |
| SCHEMBL23878364 | 0.80 | LMNA (0.46) | KDM4EMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL2714607 | 0.80 | PPARA (0.55) | EGFRMAOBPPARGBCL2LTA4H | |
| SCHEMBL20876849 | 0.80 | PPARA (0.55) | EGFRMAOBPPARGBCL2LTA4H | |
| SCHEMBL2727271 | 0.80 | PPARA (0.55) | EGFRMAOBPPARGBCL2LTA4H | |
| SCHEMBL2009888 | 0.79 | HDAC1 (0.55) | EGFRMAOBL3MBTL1NR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |