Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311818 | 0.89 | EGFR (0.53) | MAOBNR4A2NR4A1NR4A3SRD5A2 | |
| SCHEMBL483765 | 0.89 | EGFR (0.53) | MAOBNR4A2NR4A1NR4A3SRD5A2 | |
| SCHEMBL24310073 | 0.81 | PTPN1 (0.55) | PTPN1MAOBNR4A2SMPD1NR4A1 | |
| SCHEMBL2834205 | 0.81 | GPR132 (0.55) | PTPN1MAOBNR4A2GPR132CTSK | |
| SCHEMBL483714 | 0.79 | PTPN1 (0.50) | PTPN1MAOBNR4A2SMPD1NR4A1 | |
| SCHEMBL310957 | 0.76 | MAOB (0.51) | PTPN1MAOBCTSK | |
| SCHEMBL3350999 | 0.76 | ITGB3 (0.55) | PTPN1MAOBNR4A2NR4A1NR4A3 | |
| SCHEMBL840032 | 0.76 | EGFR (0.50) | MAOBNR4A2NR4A1NR4A3SRD5A2 | |
| SCHEMBL32665611 | 0.75 | SMPD1 (0.60) | PTPN1MAOBNR4A2SMPD1NR4A1 | |
| SCHEMBL2575501 | 0.75 | CHRNA1 (0.38) | MEN1KMT2ACTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |