Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839580 | 0.93 | HSD11B1 (0.52) | HSD11B1OPRM1OPRK1OPRL1HTR1D | |
| SCHEMBL4838263 | 0.93 | HSD11B1 (0.54) | HSD11B1OPRM1OPRK1OPRL1HTR1D | |
| SCHEMBL4832816 | 0.90 | HSD11B1 (0.54) | HSD11B1OPRM1OPRK1OPRL1HTR1D | |
| SCHEMBL4833114 | 0.89 | HTR1D (0.51) | OPRM1OPRK1OPRL1HTR1DHTR1A | |
| SCHEMBL4833089 | 0.88 | HSD11B1 (0.55) | HSD11B1OPRM1OPRK1OPRL1HTR1D | |
| SCHEMBL4830266 | 0.81 | HTR1D (0.51) | OPRM1OPRK1OPRL1HTR1DHTR1A | |
| SCHEMBL4833701 | 0.81 | HTR1D (0.53) | OPRM1OPRK1OPRL1HTR1DHTR1A | |
| SCHEMBL4839037 | 0.80 | ACHE (0.53) | HTR1ASLC6A4HTR7DRD2HTR6 | |
| SCHEMBL4835916 | 0.78 | ADRA1D (0.54) | OPRM1OPRK1OPRL1HTR1DHTR1A | |
| SCHEMBL4838358 | 0.78 | HTR1D (0.53) | OPRM1OPRK1OPRL1HTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384957-B2 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2008-06-10 | — | — | US | claimed |
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2005-03-31 | — | — | US | claimed |
| US-7384957-B2 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2008-06-10 | — | — | US | disclosed |
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | KCNJ2, KCNK2, KCNJ11 | HSD11B1 1314/4885OPRM1 1618/4885OPRK1 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.