Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833432 | 0.88 | MTNR1B (0.40) | POLBMTNR1BOPRD1ALDH1A1KDM4E | |
| SCHEMBL4837245 | 0.84 | ALDH1A1 (0.50) | POLBMTNR1BALDH1A1TACR3 | |
| SCHEMBL4833126 | 0.83 | ALDH1A1 (0.52) | POLBMTNR1BALDH1A1TACR3 | |
| SCHEMBL4839655 | 0.83 | OPRM1 (0.46) | POLBMTNR1BALDH1A1KDM4EHPGD | |
| SCHEMBL4837378 | 0.83 | ALDH1A1 (0.52) | POLBMTNR1BALDH1A1TACR3 | |
| SCHEMBL4830126 | 0.83 | TACR3 (0.45) | POLBDRD2TACR3 | |
| SCHEMBL4837665 | 0.83 | DRD3 (0.43) | POLBMTNR1BALDH1A1TACR2TACR1 | |
| SCHEMBL4836727 | 0.83 | POLB (0.42) | POLBMTNR1BOPRD1ALDH1A1KDM4E | |
| SCHEMBL4838204 | 0.83 | POLB (0.42) | POLBMTNR1BALDH1A1KDM4EHPGD | |
| SCHEMBL4839170 | 0.81 | POLB (0.41) | POLBMTNR1BALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384957-B2 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2008-06-10 | — | — | US | claimed |
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2005-03-31 | — | — | US | claimed |
| US-7384957-B2 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2008-06-10 | — | — | US | disclosed |
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | KCNJ2, KCNK2, KCNJ11 | POLB 4382/4885MTNR1B 621/4885OPRD1 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.