Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.65 |
| ▸ | PI4KA | P42356 | 9/20 | 0.63 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.56 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 4/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041640 | 0.95 | PI4KA (0.63) | MAPK14PI4KAPI4KBPIK3CAPIK3CD | |
| SCHEMBL8773471 | 0.79 | PIK3CA (1.00) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL30099333 | 0.76 | TGFBR1 (0.58) | MAPK14PI4KAPI4KBPIK3CAPIK3CD | |
| SCHEMBL5772031 | 0.75 | MAPK14 (0.59) | MAPK14MAPTKDM4ECYP3A4IDO1 | |
| SCHEMBL18041544 | 0.74 | MAPK14 (0.92) | MAPK14PIK3CGMAPTKDM4ECYP3A4 | |
| SCHEMBL5532470 | 0.73 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL29646253 | 0.73 | PIK3CA (0.82) | PI4KAPI4KBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5772038 | 0.73 | CYP3A4 (0.54) | MAPK14MAPTKDM4ECYP3A4IDO1 | |
| SCHEMBL12373168 | 0.72 | MAPK14 (0.73) | MAPK14PI4KAPI4KBPIK3CAPIK3CD | |
| SCHEMBL224770 | 0.72 | KDM4E (1.00) | MAPK14MAPTKDM4ECYP3A4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320995-B2 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | ELI LILLY AND COMPANY (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20050272791-A1 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | EIL LILLY AND COMPANY (US) | 2005-12-08 | — | — | US | disclosed |
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272791-A1 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | MAP3K8, MAPK8, MAPK1 | MAPK14 10/4885PI4KA 210/4885PI4KB 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.