Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | FABP6 | P51161 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18041623 | 0.95 | CYP3A4 (0.54) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL5772038 | 0.90 | CYP3A4 (0.54) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL11712219 | 0.80 | ALDH1A1 (0.58) | MAPK14CYP3A4KDM4EMAPTABL1 | |
| SCHEMBL4834100 | 0.76 | MAPT (0.44) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL4840197 | 0.75 | MAPK14 (0.65) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL4839601 | 0.74 | MAPK14 (1.00) | MAPK14CYP3A4 | |
| SCHEMBL224770 | 0.73 | KDM4E (1.00) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL18041756 | 0.72 | RAB9A (0.57) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| SCHEMBL26003342 | 0.72 | IDO1 (0.63) | MAPK14CYP3A4KDM4EMAPTIDO1 | |
| Bromide SCHEMBL31020961 | 0.71 | KDM4E (0.96) | MAPK14CYP3A4KDM4EMAPTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |