Sugi Predict

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SCHEMBL4840264

SCHEMBL4840264

CC(C)(C)OC(=O)NC(CC(=O)OCc1ccccc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 3/20 0.71
▸ CTSL P07711 2/20 0.61
▸ CTSS P25774 1/20 0.61
▸ CTSK P43235 1/20 0.61
▸ KLK7 P49862 1/20 0.60
▸ CCKBR P32239 5/20 0.59
▸ ACE P12821 1/20 0.58
▸ IL1RN P18510 3/20 0.57
▸ ERAP2 Q6P179 3/20 0.57
▸ ERAP1 Q9NZ08 3/20 0.57
▸ REN P00797 1/20 0.57
▸ NMBR P28336 2/20 0.56
▸ MAPT P10636 2/20 0.56
▸ GAA P10253 1/20 0.56
▸ HTT P42858 1/20 0.56
▸ TP53 P04637 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17547906 0.96 TACR1 (0.65) TACR1CTSLCTSSCTSKKLK7
SCHEMBL27885259 0.94 TACR1 (0.77) TACR1CTSLCTSSCTSKKLK7
SCHEMBL27885257 0.94 TACR1 (0.77) TACR1CTSLCTSSCTSKKLK7
SCHEMBL30374534 0.93 REN (0.62) TACR1CTSLCTSSCTSKKLK7
SCHEMBL27885222 0.92 TACR1 (0.70) TACR1CTSLCTSSCTSKKLK7
SCHEMBL27885225 0.92 TACR1 (0.70) TACR1CTSLCTSSCTSKKLK7
SCHEMBL27951091 0.92 TACR1 (0.74) TACR1CTSLCTSSCTSKKLK7
SCHEMBL27951092 0.92 TACR1 (0.74) TACR1CTSLCTSSCTSKKLK7
SCHEMBL29397912 0.92 TACR1 (0.82) TACR1CTSLCTSSCTSKKLK7
SCHEMBL16464197 0.92 TACR1 (0.82) TACR1CTSLCTSSCTSKKLK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7365091-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2008-04-29 — — US disclosed
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2006-12-21 — — US disclosed
US-7105539-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-09-12 — — US disclosed
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-06-22 — — US disclosed
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex BIOMEP INC. 2004-09-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX GLS, SUCNR1, PGD TACR1 3920/4885CTSL 2006/4885CTSS 1630/4885
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, PGD TACR1 3994/4885CTSL 2180/4885CTSS 1756/4885
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, GCDH TACR1 4027/4885CTSL 2287/4885CTSS 1908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.