Sugi Predict

Sugi Predict / Compounds / SCHEMBL4840478

SCHEMBL4840478

SCHEMBL4840478

CCC1(CC)OC(=O)Nc2ccccc21

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.44
▸ PDK2 Q15119 1/20 0.43
▸ PDK4 Q16654 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.40
▸ HSD11B1 P28845 3/20 0.39
▸ PGR P06401 3/20 0.38
▸ ELOVL6 Q9H5J4 2/20 0.38
▸ AKR1B1 P15121 1/20 0.38
▸ HTT P42858 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ GAA P10253 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10607545 0.82 MMP2 (0.39) POLBPDK2PDK4ALDH1A1GAA
SCHEMBL10531285 0.77 ELOVL6 (0.42) PGRELOVL6
SCHEMBL4120633 0.77 ELOVL6 (0.42) ALDH1A1HSD11B1PGRELOVL6AKR1B1
SCHEMBL3873417 0.77 ELOVL6 (0.42) PGRELOVL6
SCHEMBL13126045 0.77 ELOVL6 (0.45) POLBPDK2PDK4ALDH1A1PGR
SCHEMBL10960160 0.77 ELOVL6 (0.45) PGRELOVL6
SCHEMBL631642 0.76 PGR (0.55) PDK2PDK4ALDH1A1PGR
SCHEMBL4847776 0.75 ELOVL6 (0.38) HSD11B1PGRELOVL6HTT
SCHEMBL10956566 0.74 PGR (0.50) ALDH1A1PGRELOVL6AKR1B1GAA
SCHEMBL4847852 0.73 ELOVL6 (0.43) PGRELOVL6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7354915-B2 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2008-04-08 — — US disclosed
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-09-27 — — US disclosed
US-7247625-B2 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-07-24 — — US disclosed
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH 2005-04-21 — — US disclosed
US-4831027-A USEFUL IN TREATMENT OF CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1989-05-16 — — US disclosed
EP-0263352-A1 Imidazo-benzoxazinones, their preparation and medicaments containing these compounds Dr. Karl Thomae GmbH (DE) 1988-04-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 POLB 3630/4885PDK2 2163/4885PDK4 1893/4885
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 POLB 3630/4885PDK2 2163/4885PDK4 1893/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.