Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.44 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4840989 | 1.00 | NPC1 (0.53) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4874808 | 0.94 | ALDH1A1 (0.49) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4874816 | 0.94 | ALDH1A1 (0.49) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4835162 | 0.92 | NPC1 (0.48) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4835182 | 0.92 | NPC1 (0.48) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4837848 | 0.92 | ALDH1A1 (0.45) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4837826 | 0.92 | ALDH1A1 (0.45) | NPC1HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4839240 | 0.90 | ALDH1A1 (0.40) | NPC1HPGDALDH1A1MAPTGAA | |
| SCHEMBL4839227 | 0.90 | ALDH1A1 (0.40) | NPC1HPGDALDH1A1MAPTGAA | |
| SCHEMBL4839782 | 0.89 | USP2 (0.52) | NPC1ALDH1A1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378428-B2 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-27 | — | — | US | disclosed |
| US-20050222138-A1 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222138-A1 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | PARK7, MMP8, CDK7 | NPC1 985/4885HPGD 1185/4885ALDH1A1 2636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.