Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13134624 | 1.00 | MC4R (0.58) | MC4RSIGMAR1ACHEALDH1A1CYP1A2 | |
| Formamide SCHEMBL11158316 | 0.91 | MC4R (0.49) | MC4RSIGMAR1ACHEALDH1A1CYP1A2 | |
| SCHEMBL17763481 | 0.85 | ACHE (0.67) | MC4RSIGMAR1ACHEALDH1A1LMNA | |
| SCHEMBL17763482 | 0.85 | ACHE (0.67) | MC4RSIGMAR1ACHEALDH1A1LMNA | |
| SCHEMBL30361406 | 0.83 | LMNA (0.60) | MC4RSIGMAR1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5064520 | 0.83 | CCR1 (0.50) | ACHEDRD4 | |
| SCHEMBL5692251 | 0.83 | HRH2 (0.66) | MC4RSIGMAR1ACHECYP2D6CYP2C19 | |
| SCHEMBL20284487 | 0.83 | HRH2 (0.66) | MC4RSIGMAR1ACHECYP2D6CYP2C19 | |
| SCHEMBL14528083 | 0.83 | HRH2 (0.66) | MC4RSIGMAR1ACHECYP2D6CYP2C19 | |
| SCHEMBL25154769 | 0.81 | SIGMAR1 (0.55) | MC4RSIGMAR1ACHEALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345042-B2 | MCH antagonists for the treatment of obesity | SCHERING CORPORATION (US) | 2008-03-18 | — | — | US | disclosed |
| US-20050004121-A1 | MCH antagonists for the treatment of obesity | SCHERING CORPORATION | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004121-A1 | MCH antagonists for the treatment of obesity | MCHR1, MCHR2, MC4R | MC4R 3/4885SIGMAR1 289/4885ACHE 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.