SCHEMBL4841959

SCHEMBL4841959

O=C(NCCOc1ccc(C2(C(=O)O)CC2)cc1)[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.41
MMP8 P22894 6/20 0.35
MMP3 P08254 3/20 0.35
ALDH1A1 P00352 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
RORC P51449 4/20 0.34
TRPA1 O75762 1/20 0.34
APP P05067 1/20 0.34
PTGER3 P43115 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CACNA1B Q00975 1/20 0.34
ALOX5 P09917 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4843231 0.94 FFAR4 (0.39) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4832552 0.90 FFAR4 (0.44) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4845420 0.89 FFAR4 (0.43) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4837997 0.89 FFAR4 (0.43) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4841606 0.89 FFAR4 (0.43) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4841148 0.87 FFAR4 (0.41) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4842437 0.87 FFAR4 (0.41) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4845736 0.87 FFAR4 (0.41) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4842917 0.87 FFAR4 (0.41) FFAR4MMP8MMP3ALDH1A1NPSR1
SCHEMBL4843247 0.86 FFAR4 (0.40) FFAR4MMP8MMP3ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7465811-B2 Indoline compounds LABORATOIRES FOURNIER S.A. (FR) 2008-12-16 US disclosed
US-20080119465-A1 Novel Indoline Compounds LABORATORIES FOURNIER S.A. (FR) 2008-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119465-A1 Novel Indoline Compounds GPR119, INSR, IRS1 FFAR4 125/4885MMP8 3968/4885MMP3 3739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.