Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834686 | 0.86 | SLC6A4 (0.52) | SLC6A4HTR1A | |
| SCHEMBL4830829 | 0.84 | SLC6A4 (0.50) | SLC6A4HTR1A | |
| SCHEMBL4830814 | 0.83 | SLC6A4 (0.49) | SLC6A4HTR1A | |
| SCHEMBL4837676 | 0.82 | HTR1A (0.52) | SLC6A4HTR1A | |
| SCHEMBL4838168 | 0.81 | SLC6A4 (0.49) | SLC6A4HTR1A | |
| SCHEMBL4840057 | 0.79 | SLC6A4 (0.54) | SLC6A4HTR1A | |
| SCHEMBL4840090 | 0.77 | SLC6A4 (0.49) | SLC6A4HTR1A | |
| SCHEMBL4834761 | 0.77 | SLC6A4 (0.52) | SLC6A4HTR1A | |
| SCHEMBL4840360 | 0.77 | SLC6A4 (0.49) | SLC6A4HTR1A | |
| SCHEMBL4830718 | 0.77 | SLC6A4 (0.51) | SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432282-B2 | Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-10-07 | — | — | US | claimed |
| EP-1562596-B1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2006-08-30 | — | — | EP | claimed |
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | MERCK PATENT GMBH (DE) | 2006-03-23 | — | — | US | claimed |
| CN-1708303-A | pyridylalkyl-aminoalkyl-1H-indole derivatives as antidepressants and anxiolytics having 5-HT and serotonin reuptake inhibition | MERCK PATENT GMBH (DE) | 2005-12-14 | — | — | CN | claimed |
| EP-1562596-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GmbH (DE) | 2005-08-17 | — | — | EP | claimed |
| WO-2004047840-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | WO | claimed |
| US-7432282-B2 | Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-10-07 | — | — | US | disclosed |
| EP-1562596-B1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2006-08-30 | — | — | EP | disclosed |
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | MERCK PATENT GMBH (DE) | 2006-03-23 | — | — | US | disclosed |
| CN-1708303-A | pyridylalkyl-aminoalkyl-1H-indole derivatives as antidepressants and anxiolytics having 5-HT and serotonin reuptake inhibition | MERCK PATENT GMBH (DE) | 2005-12-14 | — | — | CN | disclosed |
| EP-1562596-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004047840-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | HTR1A, HTR1D, HTR1E | SLC6A4 22/4885HTR1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.