SCHEMBL48425

SCHEMBL48425

CN(C=O)n1cnc2c(=O)[nH]c(N)nc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 9/20 0.50
TK1 P04183 2/20 0.47
HPRT1 P00492 2/20 0.46
PNP P00491 3/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
BLM P54132 2/20 0.45
USP2 O75604 1/20 0.45
TSHR P16473 1/20 0.45
EDNRA P25101 1/20 0.45
HTR2A P28223 1/20 0.45
RECQL P46063 1/20 0.45
HBB P68871 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
CYP3A4 P08684 1/20 0.43
NFKB1 P19838 1/20 0.43
VCP P55072 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrimidine SCHEMBL27782395 0.92 XDH (0.45) XDHTK1HPRT1PNPMEN1
SCHEMBL20442302 0.85 XDH (0.55) XDHTK1HPRT1PNPMEN1
SCHEMBL23619487 0.81 XDH (0.55) XDHTK1HPRT1PNPMEN1
SCHEMBL27660450 0.76 HPRT1 (0.53) XDHTK1HPRT1PNPMEN1
SCHEMBL891817 0.75 XDH (0.52) XDHTK1HPRT1PNPMEN1
SCHEMBL1901595 0.75 XDH (0.55) XDHTK1HPRT1PNPMEN1
SCHEMBL48090 0.74 XDH (0.51) XDHTK1HPRT1PNPMEN1
9-Methylguanine SCHEMBL22884 0.74 XDH (0.58) XDHTK1HPRT1PNPMEN1
SCHEMBL986800 0.74 XDH (0.60) XDHTK1HPRT1PNPMEN1
SCHEMBL19569930 0.74 XDH (0.55) XDHTK1HPRT1PNPMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2028272-B1 METHOD OF MODIFYING NUCLEOTIDE CHAIN PANASONIC CORP (JP) 2014-01-08 EP disclosed
US-8129115-B2 Method of modifying nucleotide chain PANASONIC CORPORATION (JP) 2012-03-06 US disclosed
US-20100291637-A1 METHOD FOR MODIFYING NUCLEOTIDE CHAIN PANASONIC CORPORATION (JP) 2010-11-18 US disclosed
US-20100015670-A1 METHOD OF MODIFYING NUCLEOTIDE CHAIN PANASONIC CORPORATION (JP) 2010-01-21 US disclosed
EP-1647592-B1 METHOD OF MODIFYING NUCLEOTIDE CHAIN PANASONIC CORP (JP) 2009-03-11 EP disclosed
EP-2028272-A1 METHOD OF MODIFYING NUCLEOTIDE CHAIN Panasonic Corporation (JP) 2009-02-25 EP disclosed
US-20070077629-A1 Method for modifying nucleotide chain PANASONIC CORPORATION (JP) 2007-04-05 US disclosed
EP-1647592-A1 METHOD OF MODIFYING NUCLEOTIDE CHAIN MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 2006-04-19 EP disclosed