Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL775002 | 0.83 | NAMPT (0.56) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL17346615 | 0.83 | NAPRT (0.52) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL7906889 | 0.80 | MAPT (0.49) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL21273910 | 0.79 | TGM2 (0.49) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL10186565 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL282531 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL30209218 | 0.78 | HTT (0.50) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL3461792 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL14905920 | 0.77 | RAB9A (0.50) | SMN1; SMN2GAAHTTALDH1A1HPGD | |
| SCHEMBL9479696 | 0.77 | MAPT (0.58) | SMN1; SMN2GAAHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |