Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.39 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 10/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL4843674 | 1.00 | CHRM1 (0.39) | CHRM1DRD2DRD4DRD3HRH1 | |
| SCHEMBL14156713 | 0.94 | CHRM1 (0.43) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4838642 | 0.93 | CHRM1 (0.47) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4838630 | 0.93 | CHRM1 (0.47) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4842441 | 0.92 | CHRM1 (0.42) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4842445 | 0.92 | CHRM1 (0.42) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4843641 | 0.91 | DRD2 (0.49) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4843638 | 0.91 | DRD2 (0.49) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4844232 | 0.87 | CHRM1 (0.34) | CHRM1DRD2DRD4DRD3HRH1 | |
| Succinic Acid SCHEMBL4844238 | 0.87 | CHRM1 (0.34) | CHRM1DRD2DRD4DRD3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1546134-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | LILLY CO ELI (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20060084643-A1 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084643-A1 | Piperazine substituted aryl benzodiazepines | GABBR1, GABBR2, GABRA5 | DRD2 7/4885DRD4 27/4885DRD3 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.