Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 2/20 | 0.30 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386654 | 0.86 | PSMB8 (0.33) | PSMB8HSD11B1KMT2ALMNAL3MBTL1 | |
| SCHEMBL7836567 | 0.79 | KDM4E (0.33) | DAOAPOBEC3AAPOBEC3GKDM4EMAPT | |
| SCHEMBL4850518 | 0.78 | KDM4E (0.35) | IDO1DAOHSD17B10KDM4E | |
| SCHEMBL193935 | 0.71 | GPR3 (0.37) | SMN1; SMN2KDM4EMAPT | |
| SCHEMBL4852140 | 0.71 | AHR (0.32) | — | |
| SCHEMBL4850828 | 0.68 | — | — | |
| SCHEMBL2435048 | 0.67 | PSMB8 (0.38) | PSMB8MAT2AHSD11B1KMT2APTPN1 | |
| SCHEMBL7292482 | 0.65 | KDM4E (0.39) | KMT2ADAOHSD17B10KDM4EHCRTR1 | |
| SCHEMBL7974006 | 0.65 | ALDH1A1 (0.32) | CYP3A4SMN1; SMN2HSD17B10 | |
| SCHEMBL1093444 | 0.64 | CYP2A6 (0.53) | PSMB8L3MBTL1PTPN1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | claimed |
| US-7323488-B2 | Chromogenic enzyme substrates | BURTON MICHAEL | 2008-01-29 | — | — | US | claimed |
| EP-1436411-B1 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | BURTON MICHAEL (GB) | 2005-12-14 | — | — | EP | claimed |
| US-20050124556-A1 | Chromogenic enzyme substrates | BURTON MICHAEL (GB) | 2005-06-09 | — | — | US | claimed |
| EP-1436411-A2 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | Burton, Michael (GB) | 2004-07-14 | — | — | EP | claimed |
| WO-2003035896-A2 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | BURTON MICHAEL (GB) | 2003-05-01 | — | — | WO | claimed |
| CN-106467481-B | The synthetic method of indoles -3- aryl ketone derivatives | 昆明学院 | 2019-06-25 | — | — | CN | disclosed |
| CN-106467481-A | The synthetic method of indole 3 aryl ketone derivatives | 昆明学院 | 2017-03-01 | — | — | CN | disclosed |
| US-7323488-B2 | Chromogenic enzyme substrates | BURTON MICHAEL | 2008-01-29 | — | — | US | disclosed |
| EP-1436411-B1 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | BURTON MICHAEL (GB) | 2005-12-14 | — | — | EP | disclosed |
| US-20050124556-A1 | Chromogenic enzyme substrates | BURTON MICHAEL (GB) | 2005-06-09 | — | — | US | disclosed |
| EP-1436411-A2 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | Burton, Michael (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003035896-A2 | CHROMOGENIC ENZYME SUBSTRATES AND METHOD FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY | BURTON MICHAEL (GB) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124556-A1 | Chromogenic enzyme substrates | DCXR, MGAM, IDE | PSMB8 3578/4885MAT2A 2580/4885HSD11B1 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.