SCHEMBL4844133

SCHEMBL4844133

O=C(O)c1cccc(Cc2ccc(Cl)cc2)c1Cc1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.53
NR4A1 P22736 1/20 0.47
LMNA P02545 2/20 0.46
MAPT P10636 1/20 0.46
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
ALDH1A1 P00352 2/20 0.43
PTPN1 P18031 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
FOLH1 Q04609 1/20 0.41
FABP3 P05413 1/20 0.41
FABP4 P15090 1/20 0.41
FABP5 Q01469 1/20 0.41
MRGPRX4 Q96LA9 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4777002 0.86 TSHR (0.59) TSHRCA1CA2CA9ALDH1A1
SCHEMBL11294507 0.85 TSHR (0.54) TSHRCA1CA2CA9ALDH1A1
SCHEMBL4905340 0.85 TSHR (0.72) TSHRNR4A1LMNAMAPTCA1
SCHEMBL4848573 0.84 TSHR (0.53) TSHRCA1CA2CA9ALDH1A1
SCHEMBL7781040 0.83 TSHR (0.51) TSHRNR4A1LMNAMAPTCA1
SCHEMBL31258247 0.83 NR4A1 (0.46) TSHRNR4A1LMNAMAPTALDH1A1
SCHEMBL4360071 0.77 TSHR (0.45) TSHRNR4A1LMNAMAPTALDH1A1
SCHEMBL11464001 0.76 TSHR (0.54) TSHRNR4A1LMNAMAPTCA1
SCHEMBL27488099 0.75 ALDH1A1 (0.54) TSHRNR4A1CA1CA2CA9
SCHEMBL5455144 0.75 ALDH1A1 (0.57) TSHRNR4A1LMNAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7378374-B2 Thermally sensitive recording medium NIPPON PAPER INDUSTRIES CO., LTD. (JP) 2008-05-27 US disclosed
US-20060007765-A1 Thermal recording material NIPPON PAPER INDUSTRIES CO., LTD. (JP) 2006-01-12 US disclosed
EP-1541370-A1 THERMAL RECORDING MATERIAL Nippon Paper Industries Co., Ltd. (JP) 2005-06-15 EP disclosed