Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22438746 | 0.91 | KMT2A (0.50) | L3MBTL1TDP1PPARGMEN1HSP90AA1 | |
| SCHEMBL4851469 | 0.88 | MEN1 (0.49) | MEN1KMT2AFFAR1 | |
| SCHEMBL4847059 | 0.88 | L3MBTL1 (0.46) | L3MBTL1TDP1PPARGMEN1HSP90AA1 | |
| SCHEMBL22438768 | 0.85 | THRB (0.46) | L3MBTL1TDP1MEN1HSP90AA1KMT2A | |
| SCHEMBL1390921 | 0.85 | HPGD (0.46) | L3MBTL1TDP1PPARGMAPTMEN1 | |
| SCHEMBL31643513 | 0.82 | L3MBTL1 (0.45) | L3MBTL1TDP1PPARGMEN1HSP90AA1 | |
| SCHEMBL1390623 | 0.82 | CYP3A4 (0.63) | L3MBTL1TDP1PPARGMAPTSMN1; SMN2 | |
| SCHEMBL31643910 | 0.81 | HPGD (0.45) | L3MBTL1TDP1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4841561 | 0.80 | CYSLTR1 (0.52) | PPARGMEN1HSP90AA1KMT2AALOX5 | |
| SCHEMBL4849889 | 0.80 | F2 (0.52) | PPARGMEN1HSP90AA1KMT2AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |
| EP-1177187-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064888-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |