Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842306 | 0.91 | GPBAR1 (0.52) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6087999 | 0.89 | ALOX5 (0.55) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6090103 | 0.89 | ALOX5 (0.55) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL4846959 | 0.83 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6088409 | 0.83 | ALOX5 (0.55) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6089493 | 0.82 | ALOX5 (0.55) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL27578491 | 0.81 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL14021717 | 0.81 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL6091574 | 0.80 | ALOX5 (0.58) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL4845138 | 0.80 | L3MBTL1 (0.47) | ALOX5MEN1HSP90AA1KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |
| EP-1177187-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064888-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |