SCHEMBL644296

SCHEMBL644296

COC(=O)Cc1ccccc1N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.49
GAA P10253 1/20 0.49
GFER P55789 1/20 0.49
HSD17B10 Q99714 3/20 0.48
CFTR P13569 1/20 0.48
KDM4E B2RXH2 5/20 0.47
HPGD P15428 2/20 0.45
RCE1 Q9Y256 1/20 0.45
TSHR P16473 1/20 0.44
MEN1 O00255 1/20 0.42
USP2 O75604 1/20 0.42
APOBEC3A P31941 1/20 0.42
KMT2A Q03164 1/20 0.42
KEAP1 Q14145 1/20 0.42
NFE2L2 Q16236 1/20 0.42
APOBEC3G Q9HC16 1/20 0.42
CFD P00746 1/20 0.42
CYP4F2 P78329 1/20 0.42
CYP4A11 Q02928 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL31720563 0.98 ALDH1A1 (0.47) ALDH1A1GAAGFERHSD17B10CFTR
Hydrochloric Acid SCHEMBL1772178 0.98 ALDH1A1 (0.47) ALDH1A1GAAGFERHSD17B10CFTR
Hydrochloric Acid SCHEMBL29061400 0.96 ALDH1A1 (0.46) ALDH1A1GAAGFERHSD17B10CFTR
SCHEMBL27871547 0.86 ALDH1A1 (0.43) ALDH1A1GAAGFERHSD17B10CFTR
SCHEMBL1554320 0.86 KDM4E (0.53) ALDH1A1HSD17B10KDM4EHPGDTSHR
SCHEMBL28842276 0.85 ALDH1A1 (0.46) ALDH1A1GAAGFERHSD17B10CFTR
SCHEMBL8524830 0.84 ESR1 (0.47) ALDH1A1GAAGFERHSD17B10CFTR
SCHEMBL12883622 0.84 ALDH1A1 (0.45) ALDH1A1GAAGFERHSD17B10CFTR
SCHEMBL10268521 0.84 ALDH1A1 (0.49) ALDH1A1GAAGFERHSD17B10CFTR
SCHEMBL29749375 0.84 ALDH1A1 (0.49) ALDH1A1GAAGFERHSD17B10CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101698647-B Synthesis method of 2,5-diamino benzene ethanol YIXING XINYU CHEMICAL CO LTD 2012-10-03 CN claimed
CN-101698647-A Synthesis method of 2,5-diamino benzene ethanol YIXING XINYU CHEMICAL CO LTD 2010-04-28 CN claimed
CN-122036615-A Indazole hydrazide compound and preparation method and application thereof 南京农业大学 2026-05-15 CN disclosed
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2026-04-02 US disclosed
WO-2025137307-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. (US) 2025-06-26 WO disclosed
US-12286435-B2 Compound having benzo seven-membered ring structure, preparation method therefor, and use thereof BIONNA (BEIJING) MEDICAL TECHNOLOGY CO., LTD. (CN) 2025-04-29 US disclosed
US-20250092014-A1 COMPOUNDS AND METHODS OF ACTIVATING LIPOPROTEIN LIPASE METREA BIOSCIENCES INC (US) 2025-03-20 US disclosed
EP-4524133-A2 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS Biocryst Pharmaceuticals, Inc. (US) 2025-03-19 EP disclosed
EP-3939658-B1 SUBSTITUTED BENZOPYRROLE AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS BIOCRYST PHARM INC (US) 2024-10-02 EP disclosed
US-20240294494-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-09-05 US disclosed
US-12043610-B2 Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2024-07-23 US disclosed
EP-0642508-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1995-03-15 EP disclosed
EP-0638075-A1 THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1995-02-15 EP disclosed
WO-1994019335-A1 THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-09-01 WO disclosed
WO-1993008188-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1993-04-29 WO disclosed
EP-0313740-B1 N-PHENYL-2,2,6,6-TETRAHALOCYCLOHEXANEIMINE AND PROCESSES FOR PREPARING 2,2,6,6-TETRAHALOCYCLOHEXANEIMINE DERIVATIVE AND 2,6-DIHALOANILINE DERIVATIVE OSAKA YUKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1993-04-07 EP disclosed
US-5001264-A N-phenyl-2,2,6,6-tetrahalocyclohexaneimine and processes for preparing 2,2,6,6-tetrahalocyclohexaneimine derivative and 2,6-dihaloaniline derivative OSAKA YUKI KAGUKU KOGYO KABUSHIKI KAISHA (JP) 1991-03-19 US disclosed
US-4908479-A N-phenyl-2,2,6,6-tetrahalocyclohexaneimine OSAKA YUKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1990-03-13 US disclosed
EP-0313740-A2 N-phenyl-2,2,6,6-tetrahalocyclohexaneimine and processes for preparing 2,2,6,6-tetrahalocyclohexaneimine derivative and 2,6-dihaloaniline derivative OSAKA YUKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1989-05-03 EP disclosed
US-4803197-A ANTIINFLAMMATORY AGENTS CIBA-GEIGY CORPORATION (US) 1989-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240294494-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS C9, C5, C1QBP ALDH1A1 1047/4885GAA 2145/4885GFER 766/4885
US-12043610-B2 Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors C9, C5, C1QBP ALDH1A1 1047/4885GAA 2145/4885GFER 766/4885
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS TFPI, F3, BTK ALDH1A1 3179/4885GAA 4457/4885GFER 2822/4885
US-12286435-B2 Compound having benzo seven-membered ring structure, preparation method therefor, and use thereof BRD4, BRD7, BICRA ALDH1A1 2921/4885GAA 3511/4885GFER 3445/4885
US-20250092014-A1 COMPOUNDS AND METHODS OF ACTIVATING LIPOPROTEIN LIPASE LPL, LIPA, PNLIP ALDH1A1 1201/4885GAA 19/4885GFER 1221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.