Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.45 |
| ▸ | DNM1L | O00429 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.39 |
| ▸ | RAB9A | P51151 | 9/20 | 0.39 |
| ▸ | NPC1 | O15118 | 9/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845510 | 0.83 | AR (0.51) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL21875351 | 0.83 | ALDH1A1 (0.45) | ALDH1A1DNM1LSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4849195 | 0.76 | DNM1L (0.45) | ALDH1A1DNM1LSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4852520 | 0.76 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL4850288 | 0.72 | PPARG (0.46) | ALDH1A1SMN1; SMN2TSHRLMNAMAPT | |
| SCHEMBL28339173 | 0.70 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL15349299 | 0.67 | AR (0.51) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL20498123 | 0.66 | — | — | |
| SCHEMBL19051366 | 0.66 | AR (0.74) | ALDH1A1SMN1; SMN2HPGDHSD17B10TP53 | |
| SCHEMBL25417521 | 0.66 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2RAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368578-B2 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20060135578-A1 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1541564-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135578-A1 | Five-membered heterocyclic compounds | GPR119, OR10J3, CYP11B1 | ALDH1A1 821/4885DNM1L 3079/4885SMN1; SMN2 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.