Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.59 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 7/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854708 | 1.00 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1PTPN11THRATHRB | |
| SCHEMBL4857314 | 0.86 | MAOA (0.44) | CYSLTR2CYSLTR1BCHEACHEMAOB | |
| SCHEMBL4853507 | 0.86 | MAOA (0.44) | CYSLTR2CYSLTR1BCHEACHEMAOB | |
| SCHEMBL4854231 | 0.85 | BCHE (0.54) | BCHEACHE | |
| SCHEMBL4853732 | 0.85 | BCHE (0.54) | BCHEACHE | |
| SCHEMBL4856632 | 0.84 | SYK (0.44) | CYSLTR2BCHEACHEMAOB | |
| SCHEMBL4857214 | 0.84 | SYK (0.44) | CYSLTR2BCHEACHEMAOB | |
| SCHEMBL4853337 | 0.84 | SYK (0.44) | CYSLTR2BCHEACHEMAOB | |
| SCHEMBL4845797 | 0.84 | THRA (0.52) | CYSLTR2PTPN11THRATHRBBCHE | |
| SCHEMBL4846158 | 0.83 | BCHE (0.41) | CYSLTR2CYSLTR1BCHEACHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |