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SCHEMBL4846943

SCHEMBL4846943

COc1ccccc1-c1ccc(S(=O)(=O)NC2CCN(C(=O)OC(C)(C)C)CC2)c(C(F)(F)F)c1

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 8/20 0.56
▸ CCR8 P51685 1/20 0.51
▸ WNT3 P56703 4/20 0.50
▸ BRD4 O60885 2/20 0.50
▸ NR1H2 P55055 2/20 0.48
▸ STS P08842 1/20 0.47
▸ TGFBR1 P36897 1/20 0.46
▸ GPR119 Q8TDV5 1/20 0.46
▸ EPHX2 P34913 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4734672 0.91 SFRP1 (0.56) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4734276 0.90 SFRP1 (0.57) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4734372 0.90 SFRP1 (0.57) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4736053 0.90 SFRP1 (0.57) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4732814 0.90 SFRP1 (0.48) SFRP1WNT3
SCHEMBL4847916 0.89 SFRP1 (0.52) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4734706 0.89 SFRP1 (0.55) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4735770 0.89 SFRP1 (0.55) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4884331 0.88 SFRP1 (0.53) SFRP1CCR8WNT3BRD4NR1H2
SCHEMBL4799560 0.88 SFRP1 (0.62) SFRP1CCR8WNT3BRD4NR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed