Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851712 | 0.89 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2GPBAR1NPC1MAPT | |
| SCHEMBL14045430 | 0.86 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2GPBAR1HCRTR1HCRTR2 | |
| SCHEMBL4841561 | 0.83 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL6092289 | 0.82 | ALOX5 (0.58) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| SCHEMBL14021727 | 0.81 | CYSLTR1 (0.50) | CYSLTR1CYSLTR2GPBAR1NPC1MAPT | |
| SCHEMBL4849397 | 0.81 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1HCRTR1HCRTR2 | |
| SCHEMBL4846377 | 0.80 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2GPBAR1HCRTR1HCRTR2 | |
| SCHEMBL4848377 | 0.80 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL4848359 | 0.80 | CYSLTR1 (0.50) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL4846550 | 0.79 | CYSLTR1 (0.52) | CYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |
| EP-1177187-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064888-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |