Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 13/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847180 | 1.00 | CA1 (0.38) | CA1CA2APLNRTDP1L3MBTL1 | |
| SCHEMBL4845250 | 0.88 | CA1 (0.41) | CA1CA2APLNRTDP1L3MBTL1 | |
| SCHEMBL4848914 | 0.83 | CA1 (0.44) | CA1CA2APLNRTBXAS1IDO1 | |
| SCHEMBL3953584 | 0.82 | TBXAS1 (0.43) | CA1CA2APLNRTBXAS1 | |
| SCHEMBL5815285 | 0.81 | CA1 (0.40) | CA1CA2APLNRTBXAS1IDO1 | |
| SCHEMBL4847585 | 0.80 | CA1 (0.41) | CA1CA2APLNRTBXAS1IDO1 | |
| SCHEMBL7198518 | 0.79 | CA1 (0.40) | CA1CA2APLNRTDP1L3MBTL1 | |
| SCHEMBL7198525 | 0.79 | CA1 (0.40) | CA1CA2APLNRTDP1L3MBTL1 | |
| SCHEMBL7096896 | 0.79 | CA1 (0.40) | CA1CA2APLNRTDP1L3MBTL1 | |
| SCHEMBL5997017 | 0.79 | CA1 (0.40) | CA1CA2APLNRTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-07 | — | — | US | disclosed |
| US-7321046-B2 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2008-01-22 | — | — | US | disclosed |
| US-20060025395-A1 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | PITTSBURGH, UNIVERSITY OF | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | RPS14, RPL41, DHCR7 | CA1 3105/4885CA2 3680/4885APLNR 1408/4885 |
| US-20060025395-A1 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | DCXR, DHCR7, RRM2B | CA1 3716/4885CA2 4303/4885APLNR 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.