Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847585 | 0.91 | CA1 (0.41) | CA1CA2APLNRIDO1AGXT | |
| SCHEMBL4845250 | 0.89 | CA1 (0.41) | CA1CA2APLNRIDO1AGXT | |
| SCHEMBL5815285 | 0.86 | CA1 (0.40) | CA1CA2APLNRIDO1AGXT | |
| SCHEMBL7199332 | 0.85 | CA1 (0.41) | CA1CA2APLNRTBXAS1HDAC4 | |
| SCHEMBL7198249 | 0.85 | CA1 (0.41) | CA1CA2APLNRTBXAS1HDAC4 | |
| SCHEMBL14619682 | 0.85 | CA1 (0.41) | CA1CA2APLNRIDO1AGXT | |
| SCHEMBL3953584 | 0.85 | TBXAS1 (0.43) | CA1CA2APLNRTBXAS1HDAC4 | |
| SCHEMBL6807121 | 0.84 | CA1 (0.41) | CA1CA2APLNRIDO1AGXT | |
| SCHEMBL7190400 | 0.84 | CA1 (0.41) | CA1CA2APLNRIDO1AGXT | |
| SCHEMBL6807118 | 0.84 | CA1 (0.41) | CA1CA2APLNRIDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-07 | — | — | US | disclosed |
| US-7321046-B2 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2008-01-22 | — | — | US | disclosed |
| US-20060025395-A1 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | PITTSBURGH, UNIVERSITY OF | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | RPS14, RPL41, DHCR7 | CA1 3105/4885CA2 3680/4885APLNR 1408/4885 |
| US-20060025395-A1 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | DCXR, DHCR7, RRM2B | CA1 3716/4885CA2 4303/4885APLNR 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.