Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | CCR5 | P51681 | 6/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852736 | 0.82 | DRD2 (0.60) | DRD2ADRA1ASMN1; SMN2 | |
| SCHEMBL4854957 | 0.82 | DRD2 (0.64) | DRD2ADRA1ASIGMAR1 | |
| SCHEMBL4853485 | 0.81 | DRD2 (0.63) | DRD2ADRA1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4855743 | 0.81 | DRD2 (0.63) | DRD2ADRA1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4854584 | 0.81 | DRD2 (0.62) | DRD2ADRA1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4854617 | 0.81 | DRD2 (0.62) | DRD2ADRA1ASIGMAR1 | |
| SCHEMBL4847512 | 0.81 | DRD2 (0.71) | DRD2ADRA1A | |
| SCHEMBL4856188 | 0.80 | DRD2 (0.66) | DRD2ADRA1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL4854154 | 0.80 | DRD2 (0.61) | DRD2ADRA1A | |
| Hydrochloric Acid SCHEMBL4854158 | 0.80 | DRD2 (0.61) | DRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446204-B2 | Amino substituted aryloxybenzylpiperidine derivatives | H. LUNDBECK A/S (DK) | 2008-11-04 | — | — | US | disclosed |
| EP-1804796-A2 | AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006041636-A2 | AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES | H.LUNDBECK A/S (DK) | 2006-04-20 | — | — | WO | disclosed |
| US-20060079522-A1 | Amino substituted aryloxybenzylpiperidine derivatives | H. LUNDBECK A/S (DK) | 2006-04-13 | — | — | US | disclosed |
| US-20060079524-A1 | Amino substituted aryloxybenzylpiperidine derivatives | H. LUNDBECK A/S | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079524-A1 | Amino substituted aryloxybenzylpiperidine derivatives | MCHR1, MCHR2, MC4R | DRD2 198/4885ADRA1A 34/4885CCR5 195/4885 |
| US-20060079522-A1 | Amino substituted aryloxybenzylpiperidine derivatives | MCHR1, MCHR2, MC4R | DRD2 192/4885ADRA1A 38/4885CCR5 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.