Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854534 | 0.90 | MKNK1 (0.41) | MKNK1MKNK2KDRHRH1CHRNB2 | |
| SCHEMBL4847761 | 0.90 | MKNK1 (0.41) | MKNK1MKNK2KDRHRH1CHRNB2 | |
| SCHEMBL4850158 | 0.86 | SLC6A9 (0.41) | KDRHRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4854570 | 0.86 | HRH1 (0.41) | HRH1KDM4EALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL4849669 | 0.85 | HRH1 (0.39) | HRH1TNFRSF1AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4852988 | 0.85 | HRH1 (0.41) | HRH1KDM4EALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL4851092 | 0.83 | ALDH1A1 (0.42) | HRH1KDM4EALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL4848073 | 0.83 | HTR7 (0.41) | HRH1KDM4EALDH1A1SMN1; SMN2SLC6A9 | |
| SCHEMBL4847450 | 0.83 | SLC6A9 (0.43) | HRH1KDM4EALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL4853598 | 0.83 | MAOB (0.41) | HRH1KDM4EALDH1A1SMN1; SMN2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |