Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847800 | 0.90 | SMN1; SMN2 (0.45) | MAOBSMN1; SMN2LMNAGAAMAPT | |
| SCHEMBL4857391 | 0.90 | SMN1; SMN2 (0.45) | MAOBSMN1; SMN2LMNAGAAMAPT | |
| SCHEMBL4854762 | 0.89 | ALDH1A1 (0.42) | MAOBSMN1; SMN2KDM4EALDH1A1HRH1 | |
| SCHEMBL4851092 | 0.88 | ALDH1A1 (0.42) | SMN1; SMN2KDM4EALDH1A1HRH1SLC6A9 | |
| SCHEMBL4847450 | 0.87 | SLC6A9 (0.43) | SMN1; SMN2KDM4EALDH1A1HRH1SLC6A9 | |
| SCHEMBL4848073 | 0.87 | HTR7 (0.41) | MAOBSMN1; SMN2UTS2RKDM4EALDH1A1 | |
| SCHEMBL4853598 | 0.87 | MAOB (0.41) | MAOBSMN1; SMN2KDM4EALDH1A1HRH1 | |
| SCHEMBL4848106 | 0.86 | SLC6A9 (0.44) | SMN1; SMN2KDM4EALDH1A1HRH1SLC6A9 | |
| SCHEMBL6394376 | 0.86 | HTR7 (0.46) | MAOBSMN1; SMN2KDM4EALDH1A1HRH1 | |
| SCHEMBL4847477 | 0.86 | ALDH1A1 (0.40) | MAOBSMN1; SMN2KDM4EALDH1A1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | claimed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |