Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852794 | 0.93 | MCHR1 (0.45) | BCHEACHESLC6A9TNFRSF1APTPN1 | |
| SCHEMBL4851258 | 0.88 | BCHE (0.47) | BCHEACHESLC6A9TNFRSF1AMCHR1 | |
| SCHEMBL4854964 | 0.86 | BCHE (0.43) | BCHEACHESLC6A9TNFRSF1APTPN1 | |
| SCHEMBL4847450 | 0.86 | SLC6A9 (0.43) | BCHEACHESLC6A9PTPN1MCHR1 | |
| SCHEMBL4847119 | 0.86 | SNCA (0.41) | BCHEACHETNFRSF1ADPP4PTPN1 | |
| SCHEMBL4853297 | 0.84 | BCHE (0.52) | BCHEACHETNFRSF1AKDM4ESMN1; SMN2 | |
| SCHEMBL3688611 | 0.84 | NMT2 (0.38) | DPP4PTPN1MCHR1SNCA | |
| SCHEMBL4848146 | 0.83 | SLC6A9 (0.44) | BCHEACHESLC6A9 | |
| SCHEMBL4849675 | 0.83 | SLC6A9 (0.44) | BCHEACHESLC6A9 | |
| SCHEMBL4847435 | 0.82 | SLC6A9 (0.46) | BCHEACHESLC6A9MCHR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |