Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL593762 | 0.94 | KMO (0.60) | KMOTTRALDH1A1HPGDGPR183 | |
| SCHEMBL594366 | 0.86 | ALDH1A1 (0.57) | KMOTTRALDH1A1HPGDKDM4E | |
| SCHEMBL594127 | 0.85 | KDM4E (0.56) | KMOTTRALDH1A1HPGDKDM4E | |
| SCHEMBL592613 | 0.85 | KDM4E (0.56) | KMOTTRALDH1A1HPGDKDM4E | |
| SCHEMBL27893364 | 0.83 | KMO (0.70) | KMOALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL6629680 | 0.81 | MAPT (0.49) | KMOTTRALDH1A1KDM4EGPR183 | |
| SCHEMBL1793059 | 0.81 | KMO (0.48) | KMOALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL4757032 | 0.77 | KMO (0.62) | KMOALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL23662606 | 0.77 | MRGPRX4 (0.49) | KMOALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL593990 | 0.76 | TTR (0.53) | KMOTTRALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |