Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935256 | 0.76 | SIGMAR1 (0.51) | CYP2A6HRH3SLC6A4DRD2ASIC3 | |
| SCHEMBL5935293 | 0.75 | SIGMAR1 (0.50) | CYP2A6HRH3SLC6A4DRD2ASIC3 | |
| SCHEMBL10238584 | 0.75 | FAAH (0.56) | CYP2A6SLC6A4DRD2FAAHSLC6A3 | |
| SCHEMBL5935218 | 0.74 | SIGMAR1 (0.44) | CYP2A6SLC6A4DRD2FAAHASIC3 | |
| SCHEMBL5935243 | 0.74 | SIGMAR1 (0.43) | CYP2A6SLC6A4DRD2FAAHASIC3 | |
| SCHEMBL6696545 | 0.73 | DRD2 (0.50) | CYP2A6SLC6A4DRD2ADRB2ASIC3 | |
| SCHEMBL5332205 | 0.72 | DRD2 (0.52) | HRH3SLC6A4DRD2 | |
| SCHEMBL28394803 | 0.71 | CYP2A6 (0.55) | CYP2A6ADRB2ASIC3LOXL2 | |
| SCHEMBL15980823 | 0.71 | CYP2A6 (0.54) | CYP2A6ADRB2ASIC3LOXL2CYP2D6 | |
| SCHEMBL5935285 | 0.70 | CHRNA7 (0.47) | CYP2A6HRH3SLC6A4DRD2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393865-B2 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| WO-2006019497-A2 | SLEEP-INDUCING COMPOUNDS AND METHODS RELATED THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20060014797-A1 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014797-A1 | Sleep inducing compounds and methods relating thereto | CHRM1, CNR1, HRH3 | CYP2A6 42/4885HRH3 3/4885SLC6A4 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.