Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4851216 | 0.83 | PPARG (0.42) | — | |
| Bromide SCHEMBL19326868 | 0.79 | SNCA (0.40) | SNCAKDM4E | |
| Bromide SCHEMBL7872610 | 0.76 | SNCA (0.41) | SNCAPOLBALDH1A1 | |
| SCHEMBL16581484 | 0.74 | KDM4E (0.49) | KDM4ENPC1POLBPTK2BALDH1A1 | |
| SCHEMBL16581586 | 0.74 | KDM4E (0.49) | KDM4ENPC1POLBPTK2BALDH1A1 | |
| Water SCHEMBL4390663 | 0.73 | HTR1A (0.40) | SNCAPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL7874564 | 0.73 | HTR1A (0.40) | SNCAPOLBALDH1A1 | |
| SCHEMBL16581603 | 0.72 | KDM4E (0.50) | KDM4ENPC1POLBPTK2BALDH1A1 | |
| SCHEMBL7865387 | 0.72 | HTR1A (0.39) | SNCAPOLBALDH1A1 | |
| SCHEMBL7873044 | 0.70 | HTR1A (0.38) | SNCAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7422702-B2 | Benzene derivative having long, linear conjugated structure, process for producing benzene derivative, and liquid-crystal material | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2008-09-09 | — | — | US | disclosed |
| US-7390433-B2 | Benzene derivative having long, linear conjugated structure, process for producing benzene derivative, and liquid-crystal material | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2008-06-24 | — | — | US | disclosed |
| US-20070029520-A1 | Benzene Derivative Having Long, Linear Conjugated Structure, Process For Producing Benzene Derivative, And Liquid-Crystal Material | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| US-20060278848-A1 | Benzene derivative having long linear conjugated structure moeity, method for production thereof and liquid crystalline material | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070029520-A1 | Benzene Derivative Having Long, Linear Conjugated Structure, Process For Producing Benzene Derivative, And Liquid-Crystal Material | ABCB11, SLC43A1, SLC43A3 | SNCA 3126/4885CHRNA7 2857/4885KDM4E 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.