Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850596 | 1.00 | CCR2 (0.52) | CCR2DRD2DRD4TEAD1KMT2A | |
| SCHEMBL4840662 | 0.84 | CCR2 (0.57) | CCR2DRD2DRD4TEAD1KMT2A | |
| SCHEMBL4842849 | 0.84 | CCR2 (0.57) | CCR2DRD2DRD4TEAD1KMT2A | |
| SCHEMBL4840672 | 0.84 | CCR2 (0.57) | CCR2DRD2DRD4TEAD1KMT2A | |
| SCHEMBL6859397 | 0.78 | DRD2 (0.61) | CCR2DRD2DRD4TEAD1SIGMAR1 | |
| SCHEMBL4841172 | 0.78 | DRD4 (0.55) | CCR2DRD2DRD4SIGMAR1 | |
| SCHEMBL4850122 | 0.78 | DRD4 (0.55) | CCR2DRD2DRD4SIGMAR1 | |
| SCHEMBL22716940 | 0.76 | DRD2 (0.66) | CCR2DRD2DRD4TEAD1SIGMAR1 | |
| SCHEMBL4850115 | 0.76 | CCR2 (0.50) | CCR2DRD2DRD4TEAD1KMT2A | |
| SCHEMBL4841154 | 0.76 | CCR2 (0.50) | CCR2DRD2DRD4TEAD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390830-B1 | Remedies or prophylactics for diseases in association with chemokines | TEIJIN LIMITED (JP) | 2008-06-24 | — | — | US | disclosed |
| EP-1179341-B1 | REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES | TEIJIN LTD (JP) | 2005-11-09 | — | — | EP | disclosed |
| EP-1535909-A2 | Cyclic amine derivatives and their use as drugs | TEIJIN LIMITED (JP) | 2005-06-01 | — | — | EP | disclosed |
| US-6451842-B1 | Cyclic amine derivatives and their use as drugs | DUPONT PHARMACEUTICALS COMPANY | 2002-09-17 | — | — | US | disclosed |
| EP-1179341-A1 | REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES | TEIJIN LIMITED (JP) | 2002-02-13 | — | — | EP | disclosed |