Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.81 |
| ▸ | SHBG | P04278 | 1/20 | 0.81 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38652384 | 1.00 | ESR1 (0.81) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL13640734 | 0.90 | ESR1 (0.75) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL13966006 | 0.90 | ESR1 (0.64) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL30503014 | 0.90 | ESR1 (1.00) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL312243 | 0.90 | ESR1 (1.00) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL9474352 | 0.86 | ALOX5 (0.74) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL3817844 | 0.84 | NPC1 (0.76) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL38652442 | 0.84 | NPC1 (0.76) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL3586687 | 0.83 | ESR1 (0.81) | ESR1SHBGESR2LMNARAB9A | |
| SCHEMBL2331741 | 0.83 | LMNA (1.00) | ESR1SHBGESR2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9717706-B2 | Chromone inhibitors of S-nitrosoglutathione reductase | NIVALIS THERAPEUTICS, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20150352073-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | N30 PHARMACEUTICALS, LLC | 2015-12-10 | — | — | US | disclosed |
| US-20140163092-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | N30 PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-8669381-B2 | Chromone inhibitors of S-nitrosoglutathione reductase | N30 PHARMACEUTICALS, INC. (US) | 2014-03-11 | — | — | US | disclosed |
| US-20130274320-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | NIVALIS THERAPEUTICS, INC. | 2013-10-17 | — | — | US | disclosed |
| US-8481590-B2 | Chromone inhibitors of S-nitrosoglutathione reductase | N30 PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8476313-B2 | Heteroaryl-containing isoflavones as aromatase inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-07-02 | — | — | US | disclosed |
| US-20120295966-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | N30 PHARMACEUTICALS, LLC (US) | 2012-11-22 | — | — | US | disclosed |
| US-20090253715-A1 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-10-08 | — | — | US | disclosed |
| US-7572919-B2 | 7-Hydroxy-3-(4-hydroxyphenyl)-2-[(phenylmethyl)thio]-4H-1-benzopyran-4-one, for example; reacting deoxybenzoins with a phase transfer catalyst to provide a 2-(alkylthio)isoflavone, deprotecting the 2-(alkylthio)isoflavon, and applying selective debenzylation to form the final compound | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-08-11 | — | — | US | disclosed |
| US-7429576-B2 | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors | ENDORECHERCHE, INC. (CA) | 2008-09-30 | — | — | US | disclosed |
| US-7429576-B2 | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors | ENDORECHERCHE, INC. (CA) | 2008-09-30 | — | — | US | disclosed |
| EP-1802599-A2 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | The Ohio State University Research Foundation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2007001348-A2 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-01-04 | — | — | WO | disclosed |
| US-20060183923-A1 | Heteroaryl-containing isoflavones as aromatase inhibitors | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253715-A1 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | CYP19A1, HSD17B11, CYP21A2 | ESR1 20/4885SHBG 9/4885ESR2 32/4885 |
| US-20060183923-A1 | Heteroaryl-containing isoflavones as aromatase inhibitors | CYP19A1, HSD17B11, CYP21A2 | ESR1 20/4885SHBG 9/4885ESR2 32/4885 |
| US-20150352073-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | POR, GSR, CBR1 | ESR1 768/4885SHBG 327/4885ESR2 695/4885 |
| US-20130274320-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | POR, GSR, CBR1 | ESR1 768/4885SHBG 327/4885ESR2 695/4885 |
| US-20140163092-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | POR, GSR, CBR1 | ESR1 768/4885SHBG 327/4885ESR2 695/4885 |
| US-20120295966-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | POR, GSR, CBR1 | ESR1 768/4885SHBG 327/4885ESR2 695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.