Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.53 |
| ▸ | F2RL3 | Q96RI0 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851683 | 0.90 | POLB (0.46) | NPC1RAB9AMAPTSMN1; SMN2ERBB2 | |
| SCHEMBL4848215 | 0.83 | ALDH1A1 (0.53) | NPC1RAB9AMAPTSMN1; SMN2ERBB2 | |
| SCHEMBL4855047 | 0.81 | F2RL3 (0.48) | NPC1RAB9AMAPTSMN1; SMN2F2RL3 | |
| SCHEMBL4850224 | 0.76 | ERBB2 (0.42) | NPC1RAB9AMAPTSMN1; SMN2ERBB2 | |
| SCHEMBL7187027 | 0.73 | MAPT (0.56) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4852273 | 0.72 | KDM4E (0.50) | NPC1RAB9AMAPTSMN1; SMN2ERBB2 | |
| SCHEMBL12993127 | 0.71 | RAB9A (0.50) | RAB9AMAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4848311 | 0.70 | ALDH1A1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2F2RL3 | |
| SCHEMBL11071574 | 0.70 | ERBB2 (0.47) | NPC1RAB9AMAPTSMN1; SMN2ERBB2 | |
| SCHEMBL908844 | 0.70 | EPHA2 (1.00) | ERBB2EPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368578-B2 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20060135578-A1 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1541564-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135578-A1 | Five-membered heterocyclic compounds | GPR119, OR10J3, CYP11B1 | NPC1 822/4885RAB9A 1036/4885MAPT 4700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.