Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 4/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846089 | 0.91 | MAOB (0.55) | MAOBBCHEACHEDPP4TNFRSF1A | |
| SCHEMBL4853297 | 0.90 | BCHE (0.52) | MAOBBCHEACHETNFRSF1AKDM4E | |
| SCHEMBL4849165 | 0.88 | BCHE (0.58) | MAOBBCHEACHETNFRSF1AMAPT | |
| SCHEMBL4848052 | 0.87 | ABCG2 (0.48) | TNFRSF1AKDM4ELMNAMAPTATM | |
| SCHEMBL4845764 | 0.86 | ABCG2 (0.46) | TNFRSF1AKDM4ELMNAMAPTATM | |
| SCHEMBL4848206 | 0.84 | MCL1 (0.50) | BCHEACHETNFRSF1AABCG2 | |
| SCHEMBL4854688 | 0.84 | TUBB4A (0.48) | MAOBBCHEACHETNFRSF1AMAPT | |
| SCHEMBL4851437 | 0.84 | TUBB4A (0.48) | MAOBBCHEACHETNFRSF1AMAPT | |
| SCHEMBL4854790 | 0.83 | ABCG2 (0.50) | TNFRSF1AKDM4ELMNAMAPTATM | |
| SCHEMBL6386830 | 0.83 | ABCG2 (0.52) | MAOBBCHEACHEDPP4TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |