Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.50 |
| ▸ | BHMT | Q93088 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GSR | P00390 | 2/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL4887749 | 0.95 | PTGS1 (0.55) | PTGS1SLC7A11BHMTSLC1A1ENPEP | |
| Serine SCHEMBL6568302 | 0.92 | BHMT (0.41) | PTGS1SLC7A11BHMTSLC1A1CYP1A2 | |
| Serine SCHEMBL27873098 | 0.87 | BHMT (0.45) | PTGS1SLC7A11BHMTSLC1A1CYP1A2 | |
| Serine SCHEMBL1514152 | 0.87 | BHMT (0.45) | PTGS1SLC7A11BHMTSLC1A1CYP1A2 | |
| Serine SCHEMBL418635 | 0.87 | PTGS1 (0.67) | PTGS1SLC7A11SLC1A1ENPEPCYP1A2 | |
| Serine SCHEMBL3075852 | 0.87 | PTGS1 (0.67) | PTGS1SLC7A11SLC1A1ENPEPCYP1A2 | |
| Serine SCHEMBL16058500 | 0.87 | PTGS1 (0.67) | PTGS1SLC7A11SLC1A1ENPEPCYP1A2 | |
| Serine SCHEMBL15417923 | 0.83 | PTGS1 (0.57) | PTGS1SLC7A11BHMTSLC1A1ENPEP | |
| Isoleucine SCHEMBL5262337 | 0.81 | PTGS1 (0.43) | PTGS1SLC7A11BHMTSLC1A1ENPEP | |
| Cysteine SCHEMBL5257746 | 0.81 | PTGS1 (0.43) | PTGS1SLC7A11BHMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320784-B1 | Immobilized labeling compounds and methods | BRACCO IMAGING S.P.A. (IT) | 2008-01-22 | — | — | US | disclosed |
| EP-1047708-B1 | PEPTIDE CHELATORS THAT PREDOMINATELY FORM A SINGLE STEREOISOMERIC SPECIES UPON COORDINATION TO A METAL CENTER | BRACCO INT BV (NL) | 2007-09-26 | — | — | EP | disclosed |
| EP-1154803-B1 | IMMOBILIZED LABELING COMPOUNDS AND METHODS | BRACCO INT BV (NL) | 2004-11-17 | — | — | EP | disclosed |
| US-6334996-B1 | RADIOLABELS FOR TARGETING SPECIFIC DIAGNOSTIC PHARMACEUTICALS | RESOLUTION PHARMACEUTICALS INC. (CA) | 2002-01-01 | — | — | US | disclosed |
| EP-1154803-A1 | IMMOBILIZED LABELING COMPOUNDS AND METHODS | Bracco International B.V. (NL) | 2001-11-21 | — | — | EP | disclosed |
| EP-1047708-A1 | PEPTIDE CHELATORS THAT PREDOMINATELY FORM A SINGLE STEREOISOMERIC SPECIES UPON COORDINATION TO A METAL CENTER | RESOLUTION PHARMACEUTICALS INC. (CA) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000048639-A1 | IMMOBILIZED LABELING COMPOUNDS AND METHODS | RESOLUTION PHARMACEUTICALS INC. (CA) | 2000-08-24 | — | — | WO | disclosed |
| EP-1007106-A1 | COMBINATORIAL LIBRARY | RESOLUTION PHARMACEUTICALS INC. (CA) | 2000-06-14 | — | — | EP | disclosed |
| US-6017511-A | USING A METAL CHELATOR COUPLED TO A GLYCOPEPTIDE ANTIBIOTIC FOR IMAGING SITES OF INFLAMMATION, PARTICULARLY THOSE CAUSED BY INFECTION, IN HUMANS | RESOLUTION PHARMACEUTICALS INC. (CA) | 2000-01-25 | — | — | US | disclosed |
| WO-1999033863-A1 | PEPTIDE CHELATORS THAT PREDOMINATELY FORM A SINGLE STEREOISOMERIC SPECIES UPON COORDINATION TO A METAL CENTER | RESOLUTION PHARMACEUTICALS INC. (CA) | 1999-07-08 | — | — | WO | disclosed |
| WO-1999010016-A1 | COMBINATORIAL LIBRARY | RESOLUTION PHARMACEUTICALS INC. (CA) | 1999-03-04 | — | — | WO | disclosed |